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[2013] Æó°æ±â ³ëÈ­ À¯µµ ÀüÈÄÀÇ ·Î¾âÁ¦¸® ½ÄÀÌ°ø±ÞÀÌ ¹é¼­ Ç¥ÇÇÀÇ Çʶó±×¸°°ú À¯¸®¾Æ
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2013/04/09 637

Æó°æ±â ³ëÈ­ À¯µµ ÀüÈÄÀÇ ·Î¾âÁ¦¸® ½ÄÀÌ°ø±ÞÀÌ ¹é¼­ Ç¥ÇÇÀÇ Çʶó±×¸°°ú À¯¸®¾Æ¹Ì³ë»ê ÇÔ·® ¹× °ü·Ã ´ë»ç È¿¼ÒÀÇ ´Ü¹éÁú ¹ßÇö º¯È­¿¡ ¹ÌÄ¡´Â ¿µÇâ = The Dietary Effect of Royal Jelly Supplementation on Epidermal Levels of Filaggrin and Free Amino Acids during Menopause in Rats

http://www.riss.kr/link?id=A99595619 º¹»ç

ÃÊ·Ï ( Abstract )
  • º» ¿¬±¸¿¡¼­´Â ³­¼ÒÀýÁ¦¸¦ ÅëÇÏ¿© Æó°æ±â°¡ À¯µµµÈ ¹é¼­ ¸ðµ¨¿¡¼­ »ý»êÁö°¡ ´Ù¸¥ ±¹³»»ê ·Î¾âÁ¦¸® ½ÄÀÌ¿Í À̼ÒÇöóº»À» ½ÄÀÌ·Î °ø±ÞÇÑ ÈÄ Ç¥ÇÇÀÇ Çʶó±×¸° ¹× À¯¸®¾Æ¹Ì³ë»êÀÇ ÇÔ·®°ú °ü·Ã ´ë»ç È¿¼ÒÀÇ ¹ßÇö º¯È­¸¦ Á¤»ó´ëÁ¶±ºÀÎ SHAM±º ¹× ³­¼ÒÀýÁ¦±ºÀÎ OVX±º°ú ºñ±³¡¤ºÐ¼®ÇÏ¿´´Ù. Profilaggrin, filaggrin ¹× total filaggrinÀÇ ¹ßÇöÀº SHAM±º> RJ2±º> OVX±º=IF±º> RJ1±º ¼øÀ¸·Î RJ1±ºÀÇ profilaggrin, filaggrinÀÇ ¹ßÇö·®ÀÌ °¡Àå ³·°Ô ³ªÅ¸³µ´Ù. Profilaggrin¿¡¼­ filaggrinÀ¸·Î, filaggrin¿¡¼­ À¯¸®¾Æ¹Ì³ë»êÀ¸·ÎÀÇ ºÐÇØÇÏ´Â °úÁ¤¿¡ °ü¿©ÇÏ´Â ¿©·¯ È¿¼Ò Áß¿¡ PAD3ÀÇ ¹ßÇöÀº RJ2±º¿¡¼­ °¡Àå ³ô¾ÒÀ¸³ª SHAM±ºÀ» ºñ·ÔÇÏ¿© OVX±º, RJ1±º, IF±º¿¡¼­´Â ±º°£ À¯ÀǼºÀÌ ¾ø¾ú´Ù. Àüü À¯¸®¾Æ¹Ì³ë»êÀÇ ÇÔ·®Àº SHAM±º¿¡ ºñÇØ OVX±º¿¡¼­ ´Ù¼Ò °¨¼ÒÇÏ¿´À¸³ª RJ1±º ¹× IF±º¿¡¼­ SHAM±ºº¸´Ù ³ô°Ô ³ªÅ¸³µ´Ù. ƯÈ÷ RJ1±º¿¡¼­ aspartate¿Í prolineÀÇ ÇÔ·®ÀÌ SHAM±º¿¡ ºñÇØ ÇöÀúÈ÷ ³ô¾ÆÁ³´Ù. °á·ÐÀûÀ¸·Î RJ1±º¿¡¼­´Â filaggrinÀÇ ÇÔ·® °¨¼Ò°¡ ÀÖ¾úÁö¸¸ Ç¥ÇÇ º¸½À À¯Áö±â´ÉÀÌ ÀÖ´Â aspartate ¹× prolineÀ» ºñ·ÔÇÑ Àüü À¯¸®¾Æ¹Ì³ë»êÀÇ ÇÔ·®ÀÌ ³ô¾ÆÁ³´Ù. RJ1±ºÀÇ ·Î¾âÁ¦¸®°¡ Æó°æÀ¸·Î ÀÎÇØ °¨¼ÒµÇ´Â Ç¥ÇÇÀÇ º¸½ÀÀÎÀÚ Áß ±Ã±ØÀûÀ¸·Î ÇǺΠº¸½À¿¡ °ü¿©Çϴ õ¿¬º¸½ÀÀÎÀÚÀÇ À¯¸®¾Æ¹Ì³ë»êÀÇ ¹ßÇöÀ» Áõ°¡½ÃÄÑ ¼Õ»óµÈ Ç¥ÇÇÀÇ À庮±â´É º¸¿Ï¿¡ ±àÁ¤Àû ¿µÇâÀ» º¸¿´´Ù. RJ2±ºÀº profilaggrin, filaggrinÀ» Æ÷ÇÔÇÑ total filaggrinÀÇ ÇÔ·®ÀÌ Áõ°¡µÇ¾úÀ¸³ª ±× ºÐÇػ깰ÀÎ À¯¸®¾Æ¹Ì³ë»êÀÇ ÇÔ·®Àº SHAM±º°ú À¯»çÇÏ¿´´Ù. RJ2±ºÀÇ ·Î¾âÁ¦¸®°¡ À¯¸®¾Æ¹Ì³ë»êÀÇ Àü±¸´Ü¹éÁúÀÇ ¹ßÇö Áõ°¡¸¦ ¾ß±âÇϳª À¯¸®¾Æ¹Ì³ë»êÀ¸·ÎÀÇ ºÐÇØ´Â ÃËÁø½ÃÅ°Áö ¸øÇÏ¿´À½À» ½Ã»çÇÑ´Ù. ÀÌ´Â »êÁöº° ·Î¾âÁ¦¸®ÀÇ ÇǺΠº¸½À ±â´É¿¡ ¹ÌÄ¡´Â ¿µÇâÀÌ ´Ù¸£°Ô ³ªÅ¸³¯ ¼ö ÀÖÀ½À» ÀǹÌÇϸç ÃßÈÄ °¢ »êÁöº° À¯È¿¼ººÐÀÇ ºÐ¼®°ú ÇÔ²² °ü·Ã È¿´É¿¡ ´ëÇÑ ¿¬±¸°¡ ÀÌ·ç¾îÁú Çʿ伺ÀÌ ÀÖ´Ù. º» ¿¬±¸¿¡¼­ ±¹³»»ê ·Î¾âÁ¦¸®ÀÇ ½ÄÀÌ °ø±ÞÀÌ ÇǺΠº¸½À °ü·Ã °Ç°­±â´É½ÄÇ° °³¹ß ¼ÒÀç·Î¼­ÀÇ °¡´É¼ºÀÌ ÀÖÀ» °ÍÀ¸·Î »ç·áµÈ´Ù.
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  • Epidermal hydration is mainly maintained by natural moisturizing factors (NMFs). Of these various NMFs, free amino acids (AAs) are major constituents generated by filaggrin degradation. The reduction of these AAs has been reported in aging skin induced during menopause. In this study, we examined whether the dietary supplementation of royal jelly (RJ) during the pre- and post-menopausal period alters epidermal levels of filaggrins, free AAs, and peptidylarginine deiminase-3 (PAD-3) (an enzyme involved in filaggrin degradation processes). Sprague Dawley rats were divided into five groups: groups fed a control diet for 12 weeks, in which an ovariectomy (OVX) or sham operation (SHAM) were underwent at week 4; groups fed a diet with 1% RJ harvested in different area of Korea (RJ1 and RJ2); and a group fed a diet with isoflavone (IF), the typical functional food for menopause prevention, for 4 weeks before and 8 weeks after an ovariectomy operation. In the epidermis of group OVX, total filaggrins (including profilaggrin and filaggrin) were reduced; these levels in groups RJ1 and IF were similar or less than in group OVX. However, total AAs, which showed no apparent difference between groups SHAM and OVX, were highly increased in groups RJ1 and IF. Specifically, aspartate (Asp) and proline (Pro), the major AAs in functioning NMF, were highly increased in group RJ1. Although total filaggrins, profilaggrin, filaggrin and PAD3 increased, total AAs (including Asp and Pro) in group RJ2 were modest or less than in group RJ1. The PAD3 alteration was not apparent among the four other groups. Taken together, we demonstrate that the diet supplementation of RJ1 enhanced filaggrin degradation (but not through the increased protein expression of PAD3), and increased total AAs, Asp and Pro. RJ1 could be a dietary supplementation for preventing the skin aging induced during menopause.


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