[2012] Royal Jelly Increases Collagen Production in Rat Skin After Ovariectomy
2012/07/12 4287
jmf.2011.pdf ( 387.9 K | 다운 : 293 )
 2012 Jun;15(6):568-75. doi: 10.1089/jmf.2011.1888. Epub 2012 Apr 2.

Royal jelly increases collagen production in rat skin after ovariectomy.


Department of East-West Medical Science, Kyung Hee University, Yongin-si, Korea.


Royal jelly (RJ) is a honeybee product that contains proteins, carbohydrates, fats, free amino acids, vitamins, and minerals. RJ has been reported to have antitumor, antibacterial, and wound-healing activities. We previously reported that RJ enhanced the migration of human dermal fibroblasts and altered the levels of cholesterol and sphinganine in an in vitro wound-healing model in addition to regulating skin photoaging following exposure to ultraviolet-B radiation. We established an animal model of skin aging in the context of estrogen deficiency and assessed the antiaging effects of RJ on skin. To establish an in vivo model of skin aging, bilateral ovariectomies were performed in 12-week-old virgin female Sprague-Dawley rats. Induction of osteoporosis was confirmed through two-dimensional images of the trabecular bone in the left femoral necks using microcomputed tomography. The protective effects of RJ ovariectomy-induced skin aging were examined by determining the protein expression of type I procollagen and matrix metalloproteinase (MMP)-1. The collagen content and epidermal thickness of skin tissue were measured by staining techniques. There was a significant difference in weight between sham-operated and ovariectomized groups. Food efficiency ratio did not differ significantly among the groups. The level of procollagen type I protein was increased in the dorsal skin of ovariectomized rats fed with a dietary supplement containing 1% RJ extract, but the level of MMP-1 was not altered. In particular, the amount ofcollagen recovered was close to the normal level. RJ may protect against skin aging by enhancing collagen production in rats with ovariectomy-induced estrogen deficiency.

[PubMed - indexed for MEDLINE] 
 [Available on 2013/6/1]

게시판 리스트
44   [2018] Borage oil restores acidic skin pH by ... 관리자 2018-08-30 312
43   [2017] Royal Jelly Supplementation Ameliorate... 관리자 2018-08-30 55
42   [2017] Pilot study on the correlation between... 관리자 2018-08-30 47
41   [2017] 건강한 성인에서 피부 산도와 영양소 섭취... 관리자 2018-08-30 136
40   [2016] Structural identification of skin cera... 관리자 2018-08-30 5234
39   [2016] 자외선 조사와 병행된 녹차 식이 공급이 ... 관리자 2018-08-30 57
38   [2016] Associations among plasma vitamin C, e... 관리자 2018-08-30 537
37   [2016] 자외선 조사와 병행된 녹차추출물 식이공... 관리자 2018-08-30 61
36   [2015] Mass Spectrometric Confrmation of γ&a... 관리자 2018-08-30 64
35   [2015] 필수지방산 결핍이 유도된 기니피그에서 ... 관리자 2018-08-30 1116
34   [2015] Vitamin C Stimulates Epidermal Ceramid... 관리자 2018-08-30 51
33   [2015] Epidermal Hydration Is Improved by Enh... 관리자 2018-08-30 62
32   [2014] 산화적 스트레스를 유발시킨 HepG2 세포에... 관리자 2018-08-30 48
31   [2014] Lipopolysaccharide로 자극된 복강 대식세... 관리자 2018-08-30 47
30   [2014] Increased OPG/RANKL ratio in the condi... 관리자 2018-08-30 55
29   [2013] Gromwell (Lithospermum erythrorhizon) ... 관리자 2013-12-31 154
28   [2013]Altered levels of sphingosine and sphin... 관리자 2013-12-31 1567
27   [2013] 자외선 조사와 병행된 로얄제리 식이 공급... 관리자 2013-06-25 8049
26   [2013] 폐경기 노화 유도 전후의 로얄제리 식이공... 관리자 2013-04-09 420
  [2012] Royal Jelly Increases Collagen Product... 상훈 2012-07-12 4287